![Stimulus-Response Pathway Stimulus-Response Pathway](https://i.kym-cdn.com/entries/icons/mobile/000/035/963/cover1.jpg)
Stimulus-Response Pathway
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About
Stimulus-Response Pathway refers to a series of memes based on a scientific diagram depicting the stimulus-response pathway in the human body. The format gained popularity in late October 2020 with edits in which various memes and characters triggered a reaction of liking or sharing them. The format is similar to Neuron Activation.
Origin
The scientific diagram used in the format illustrates the stimulus-response pathway of the human nervous system (shown below). While the exact origin of the diagram is unknown, starting in 2016, it was featured in a number of articles and posts online, including posts on BioNinja[1] and Socratic.[2]
![Stimulus-Response Pathway Diagram Sensory Neuron Stimulus Receptor Relay Neuron Brain (CNS) Motor Neuron Response Effector](https://i.kym-cdn.com/photos/images/newsfeed/001/955/092/b62.jpeg)
The diagram did not see use in memes until late October 2020. On October 18th, 2020, Twitter[7] user @kiaenq posted the first meme which used the diagram a template; a Touhou meme. The post received over 1,300 retweets and 3,800 likes in two months (shown below).
![It's Cirno](https://a.kym-cdn.com/assets/blank-b3f96f160b75b1b49b426754ba188fe8.gif)
Spread
On October 20th, Redditor[3] Muraaaaaaa posted the first derivative meme; a League of Legends joke. The post received over 940 upvotes in one month (shown, below center). On the same day, Twitter[4] user @chikakusareta posted a meme about WataMote character Tomoko that gained over 80 retweets and 250 likes (shown below, right).
![Pyke Mains Be Like Sensory Neuron (+300 Stimulus Receptor Relay Neuron Brain (CNS) Motor Neuron Response Effector](https://i.kym-cdn.com/photos/images/newsfeed/001/955/096/188.jpg)
![Tomoko... Sensory Neuron Tomoko Stimulus Receptor Relay Neuron Brain (CNS) Motor Neuron Response Effector](https://a.kym-cdn.com/assets/blank-b3f96f160b75b1b49b426754ba188fe8.gif)
Starting in late October 2020, the format gained moderate popularity across all major platforms. For example, on October 22nd, 2020, Instagram[5] account barbells_and_anime_milkers posted a meme that received over 2,500 likes in one month (shown below, left). On October 24th, Redditor[6] from_brasil posted a Big Floppa meme that gained over 900 upvotes in /r/196 in the same period.
![Lift It For Her Sensory Neuron LET'S F------ GO!! Stimulus Receptor Relay Neuron Brain (CNS) Motor Neuron Response Effector](https://i.kym-cdn.com/photos/images/newsfeed/001/955/099/603.jpg)
![Floppa Gets an Upvote Sensory Neuron Floppa Stimulus Receptor Relay Neuron Brain (CNS) Motor Neuron Response Effector](https://i.kym-cdn.com/photos/images/newsfeed/001/955/102/480.jpg)
In October and November 2020, the format maintained a moderate popularity, with several viral tweets posted during that period.
Related Memes
Neuron Activation/ Monkey Sees Action
Neuron Activation, also known as Monkey Sees Action, refers to an abridged scientific diagram illustrating firing of a mirror neutron in a monkey upon observing another monkey eating a banana. Starting in February 2020, the diagram has been used as an exploitable, with the image of the second monkey usually replaced with other imagery.
![Simp Activation Simp activation e-girl Monkey sees e-girl UwU](https://a.kym-cdn.com/assets/blank-b3f96f160b75b1b49b426754ba188fe8.gif)
![Monkey Sees Vtuber Neuron activation Monkev sees vtuber](https://a.kym-cdn.com/assets/blank-b3f96f160b75b1b49b426754ba188fe8.gif)
Various Examples
![МЫШ Sensory Neuron rat Stimulus Receptor Relay Neuron Brain (CNS) Motor Neuron Response Effector](https://i.kym-cdn.com/photos/images/newsfeed/001/955/103/d3d.jpg)
![Stimulus: Craig the Brute Sensory Neuron heehoo monkey Stimulus Receptor Relay Neuron Brain (CNS) Motor Neuron Response Effector](https://a.kym-cdn.com/assets/blank-b3f96f160b75b1b49b426754ba188fe8.gif)
![Stimulus: Makima Sensory Neuron its makima Stimulus Receptor Relay Neuron Brain (CNS) Motor Neuron Response Effector](https://i.kym-cdn.com/photos/images/newsfeed/001/955/108/973.jpg)
![Stimulus: Doge Sensory Neuron Doge Stimulus Receptor Relay Neuron Brain (CNS) Motor Neuron Response Effector](https://a.kym-cdn.com/assets/blank-b3f96f160b75b1b49b426754ba188fe8.gif)
![Stimulus: Thick Thighs Sensory Neuron Thick Stimulus Receptor Relay Neuron Brain (CNS) Motor Neuron Response Effector](https://a.kym-cdn.com/assets/blank-b3f96f160b75b1b49b426754ba188fe8.gif)
![Stimulus: Kat Sensory Neuron it's kat Stimulus Receptor Relay Neuron Brain (CNS) Motor Neuron Response Effector](https://a.kym-cdn.com/assets/blank-b3f96f160b75b1b49b426754ba188fe8.gif)
Template
![Stimulus-Response Pathway Meme Template Sensory Neuron Stimulus Receptor Relay Neuron Brain (CNS) Motor Neuron Response Effector](https://i.kym-cdn.com/photos/images/newsfeed/001/955/119/acf.jpg)
Search Interest
External References
[1] BioNinja – Stimulus-Response
[2] Socratic – In response to a stimulus there is immediate reaction. What kind of neurons are involved in the process?
[3] Reddit – I created someting
[4] Twitter – @chikakusareta
[5] Instagram – barbells_and_anime_milkers
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